Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interlamellar lipid differences between normal and psoriatic stratum corneum

S Motta1, S Sesana, M Monti

  • 11st Clinic of Dermatology, University of Milano, Italy.

Acta Dermato-Venereologica. Supplementum
|January 1, 1994
PubMed
Summary

Psoriasis alters skin barrier lipids, significantly reducing free fatty acids in psoriatic scales compared to healthy skin. This suggests keratinocytes may utilize free fatty acids during disease.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prospective biomarkers of posttraumatic stress disorder in children and adolescents: a systematic review and meta-analysis.

Translational psychiatry·2026
Same author

Half-Life and Precision Shape Measurement of the 2νββ Decay of ^{130}Te.

Physical review letters·2025
Same author

Primary subtalar arthrodesis in displaced intra-articular calcaneal fracture: a systematic review.

Musculoskeletal surgery·2025
Same author

Occupational Rhinoconjunctivitis Induced by Flaxseed: Identification of Novel Allergenic Proteins From Cupin, Chaperonin, and Enzyme Families.

Journal of investigational allergology & clinical immunology·2025
Same author

First Observation of a Nuclear Recoil Peak at <math></math> (100eV) with Crab: A Potential New Calibration Standard for Cryogenic Detectors.

Journal of low temperature physics·2025
Same author

Search for Fractionally Charged Particles with CUORE.

Physical review letters·2025

Area of Science:

  • Biochemistry
  • Dermatology
  • Skin Barrier Function

Background:

  • Intercellular lipids in the stratum corneum are crucial for skin permeability barrier integrity.
  • Psoriasis is associated with altered desquamation and permeability barrier homeostasis, indicating changes in lipid production.

Purpose of the Study:

  • To quantify and compare the content of three main intercellular lipids in psoriatic scales versus normal human stratum corneum.
  • To investigate the role of lipid alterations in the pathogenesis of psoriasis.

Main Methods:

  • Analysis of intercellular lipid content in psoriatic scales.
  • Comparison with lipid profiles of normal human stratum corneum.

Main Results:

  • A significant 46% reduction in relative free fatty acid content was observed in psoriatic scales.

Related Experiment Videos

  • The content of other major intercellular lipids (ceramides, cholesterol) was also assessed for comparison.

    • Conclusions:

    • The marked decrease in free fatty acids in psoriatic scales suggests a potential depletion or altered metabolism.
    • This finding may indicate a cellular response where keratinocytes utilize free fatty acids under stress conditions associated with psoriasis.