Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Psoriasis and endothelins

G Trevisan1, G Stinco, C Giansante

  • 1Institute of Dermatology, University of Trieste, Italy.

Acta Dermato-Venereologica. Supplementum
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effectiveness of guselkumab in patients with facial and/or genital psoriasis: Interim analysis results at Week 12 from the GULLIVER study.

Journal of the European Academy of Dermatology and Venereology : JEADV·2024
Same author

Acquired SERPINC1/antithrombin deficiency during oral contraceptive consumption: a case report.

Journal of medical case reports·2023
Same author

Impact of migration on diabetes burden: audit in the metropolitan area of Bologna, Italy.

Journal of endocrinological investigation·2023
Same author

Transient plasma viral rebound after SARS-CoV-2 vaccination in an exceptional HIV-1 elite controller woman.

Virology journal·2023
Same author

Dermoscopic spectrum of mycosis fungoides: a retrospective observational study by the International Dermoscopy Society.

Journal of the European Academy of Dermatology and Venereology : JEADV·2022
Same author

Bullous pemphigoid in a young male after COVID-19 mRNA vaccine: a report and brief literature review.

Journal of the European Academy of Dermatology and Venereology : JEADV·2021
Same journal

Atopic eczema - new insights in the definition, diagnostics and disease management. Proceedings of a LEO eczema workshop. November 2003. Copenhagen, Denmark.

Acta dermato-venereologica. Supplementum·2006
Same journal

Atopic hand eczema and treatment strategies.

Acta dermato-venereologica. Supplementum·2005
Same journal

Epidemiology and job-related problems for the eczema patient.

Acta dermato-venereologica. Supplementum·2005
Same journal

Treatment strategies and compliance for the adult patient with atopic eczema.

Acta dermato-venereologica. Supplementum·2005
Same journal

Compliance among patients with atopic eczema.

Acta dermato-venereologica. Supplementum·2005
Same journal

Contact allergic reactions in patients with atopic eczema.

Acta dermato-venereologica. Supplementum·2005
See all related articles

Psoriasis patients show significantly higher plasma levels of Endothelin-1 and 2. These findings suggest a potential link between elevated endothelin levels and the pathogenesis of psoriasis, requiring further investigation.

Area of Science:

  • Dermatology
  • Cardiovascular Research
  • Peptide Signaling

Background:

  • Psoriasis involves abnormal keratinocyte proliferation, inflammation, and microangiopathy.
  • Endothelins are peptides known for cardiovascular effects, with emerging roles in skin biology.
  • Keratinocytes can produce endothelin-1, influencing fibroblast proliferation and skin microcirculation.

Purpose of the Study:

  • To investigate plasma levels of Endothelin-1 and 2 in patients with psoriasis.
  • To explore the potential role of endothelin-1 and 2 in the pathophysiology of psoriasis.

Main Methods:

  • Radioimmunoassay was used to measure plasma Endothelin-1 and 2 levels.
  • A study cohort included 30 participants: 10 psoriasis patients, 10 cardiovascular disease patients, and 10 healthy controls.

Related Experiment Videos

Main Results:

  • Psoriatic patients exhibited significantly elevated plasma levels of Endothelin-1 and 2 compared to control groups.
  • This increase was observed in patients with moderate psoriasis (PASI 5-10).

Conclusions:

  • Elevated plasma Endothelin-1 and 2 levels are associated with psoriasis.
  • Further research is needed to elucidate the specific role of endothelin-1 and 2 in the pathogenesis of psoriasis.