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Updated: Aug 8, 2026
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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
Topical calcipotriol (MC 903) for psoriasis: a clinical study
N Mozzanica1, A Cattaneo, E Schmitt
1Department of Dermatology, University of Milan, Italy.
Acta Dermato-Venereologica. Supplementum
|January 1, 1994
Summary
Calcipotriol ointment effectively treated chronic plaque psoriasis in a 6-week study. Most patients showed significant improvement with minimal side effects, demonstrating its efficacy and tolerability for psoriasis management.
Area of Science:
- Dermatology
- Pharmacology
- Cell Biology
Background:
- Calcipotriol is a vitamin D3 analogue that affects keratinocyte proliferation and differentiation.
- It is a non-calcemic agent, suggesting a favorable safety profile regarding calcium metabolism.
Purpose of the Study:
- To evaluate the efficacy and tolerability of calcipotriol ointment in patients with chronic plaque-type psoriasis.
- To assess the treatment outcomes after a 6-week period of twice-daily application.
Main Methods:
- Twenty patients diagnosed with chronic plaque-type psoriasis were enrolled.
- Participants applied calcipotriol ointment (50 ng/g) twice daily for six weeks.
- Efficacy was measured by changes in the Psoriasis Area and Severity Index (PASI) score.
Main Results:
- A statistically significant decrease in PASI scores was observed in 17 out of 20 patients after 6 weeks.
- One patient showed no improvement, and two patients experienced local adverse events.
- No instances of hypercalcemia or other laboratory abnormalities were reported.
Conclusions:
- Calcipotriol ointment demonstrates significant efficacy in treating chronic plaque-type psoriasis over a 6-week period.
- The treatment is generally well-tolerated, with a low incidence of local adverse events and no systemic toxicity.
- Calcipotriol ointment is a viable therapeutic option for managing psoriasis.
