[Clinical impact of neoadjuvant treatment to radical prostatectomy in locally advanced prostatic cancer]

Thirty-five patients underwent a protocol of neo-adjuvant hormonal suppression previous to radical surgery in locally advanced stages, seven patients in stage B (T2) and 25 in stage C (T3). Three cases were not considered suitable for surgery since no clinical evidence of sub-staging was demonstrated. Clinical reassessment after neo-adjuvant therapy was conducted by rectal examination, PSA and transrectal ultrasound. Pre-hormonal average of PSA was 38.20 ng/ml (range: 1-235). Post-hormonal average was 1.15 ng/ml (range < 0.5-6.2). Clinical reduction of prostate volume was seen in 75% of patients. In three of them (9.37%) no tumour (Po) was seen in the pieces of prostatectomy.