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Updated: Sep 24, 2026

An Orthotopic Murine Model of Human Prostate Cancer Metastasis
Published on: September 19, 2013
Human prostate cancer cells: inhibition of proliferation by vitamin D analogs
G G Schwartz1, T A Oeler, M R Uskoković
1Department of Clinical Epidemiology and Family Medicine, University of Pittsburgh Medical Center, PA.
Abstract:
1,25-Dihydroxyvitamin D [1,25(OH)2D3, calcitriol] can inhibit the proliferation of some human prostate cancer cells but its clinical use is limited by hypercalcemia. We therefore explored the bioactivity of less calcemic vitamin D analogs. We studied the effects of calcitriol and 3 synthetic analogs at concentrations of 10(-6) to 10(-12) M on the in vitro proliferation of 3 human prostate carcinoma cell lines: DU 145, PC-3, and LNCaP. Calcitriol and analogs showed significant antiproliferative activity on PC-3 and LNCaP cells. DU 145 cells were inhibited by the analogs only. We conclude that vitamin D analogs warrant further investigation as therapeutic agents in prostate cancer.
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