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Structural analysis of c-myc in human sporadic colorectal carcinomas
I Albanese1, M Alberti, V Bazan
1Dipartimento di Biologia Cellulare e dello Sviluppo, University of Palermo, Italy.
Anticancer Research
|May 1, 1994
Abstract:
Analysis of the DNA extracted from the colonic mucosa of 13 patients operated for colorectal carcinoma revealed c-myc rearrangements in three of them. In all cases, the alterations were found both in the histologically normal and in the tumoral mucosa. In one case, a different pattern of rearrangements characterized the two tissues. In all three individuals, the c-myc sequences appeared to be amplified. We suggest that c-myc rearrangements in the histologically normal colonic mucosa of colorectal carcinoma patients could represent a predisposition factor for the development of additional neoplasms.