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Updated: Aug 9, 2026

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)
07:02

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)

Published on: September 14, 2010

Gene amplification and multiple mutations of the K-ras oncogene in Kaposi's sarcoma

A Nicolaides1, Y Q Huang, J J Li

  • 1Department of Microbiology, New York University Medical Center, NY 10016.

Anticancer Research
|May 1, 1994
PubMed

Insights

Alterations in the K-ras oncogene were found in Kaposi

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Kaposi's sarcoma (KS) is an unusual neoplasm.
  • The K-ras oncogene's role in KS progression is not fully understood.

Purpose of the Study:

  • To investigate alterations in the K-ras oncogene in Kaposi's sarcoma.
  • To correlate K-ras gene changes with KS clinical stages.

Main Methods:

  • Analysis of 31 Kaposi's sarcoma biopsy samples.
  • Utilized differential PCR, SSCP, and nucleic acid sequencing.
  • Examined K-ras oncogene alterations, specifically mutations in exon 1.

Main Results:

  • K-ras gene amplification detected in 3 KS specimens.
  • Mutations in K-ras exon 1 found in 7 KS specimens.
  • 8 out of 10 K-ras alterations were observed in advanced nodular stage KS, compared to 2 in plaque stage.

Conclusions:

  • K-ras oncogene alterations are present in Kaposi's sarcoma.
  • These alterations, particularly in advanced stages, suggest a role in KS malignant progression.

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