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[Toxic melanoderma in chronic intoxication with trinitrotoluene]

R G Cherkasskaia, V V Razumov, V A Semenikhin

    Meditsina Truda I Promyshlennaia Ekologiia
    |January 1, 1993
    PubMed
    Summary

    Trinitrotoluene exposure can cause hyperkinetic atactic syndrome and melanoderma, linked by a biochemical pathway affecting melanin synthesis. Antioxidant therapy shows promise for treating these conditions.

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    Area of Science:

    • Neurology
    • Biochemistry
    • Toxicology

    Background:

    • Hyperkinetic atactic syndrome is an atypical neurologic disorder.
    • Trinitrotoluene (TNT) exposure can lead to melanoderma (skin discoloration).
    • A chemical origin is suspected for these conditions.