Calcitonin gene-related peptide and the kidney

Calcitonin gene-related peptide (CGRP) is a recently discovered neurotransmitter that is extensively localized in fibers innervating vascular and endocrine systems. CGRP possesses potent vasorelaxant effects, and a role for this peptide in the regional regulation of blood flow has been suggested. Although pharmacologic evidence indicates that the renal vasculature is very sensitive to CGRP, the physiologic actions of this peptide on the kidney have not yet been fully elucidated. This short review focuses on relevant experimental and clinical information of the direct and indirect effects of CGRP on renal function with an emphasis on hemodynamics, sodium excretion, and the renin-angiotensin system.