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Potential diagnostic implications of breakpoints in the long arm of chromosome 8 in lipoblastoma
J R Sawyer1, E A Parsons, M L Crowson
1Department of Pathology, University of Arkansas for Medical Sciences, Little Rock.
Cancer Genetics and Cytogenetics
|August 1, 1994
Abstract:
We report a case of lipoblastoma in a 17-month-old male patient with a pseudodiploid karyotype of 46,XY,der(14)t(8;14)(q11.2;q24). The tumor cells show two normal chromosome 8 homologs in addition to the extra 8q11.2-->qter segment, making it trisomic for the region 8q11.2-->qter, and monosomic for 14q24-->qter. Reports of chromosome studies in lipoblastoma are rare; however, a breakpoint in the long arm of chromosome 8q11-13 appears to be emerging as a consistent finding.