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A quantitative structure-activity relationship study of ligands exhibiting agonist and antagonist actions with
P Singh1, S Tiwari, R C Sharma
1Department of Chemistry, S K Government College, Sikar, India.
Indian Journal of Biochemistry & Biophysics
|February 1, 1994
Abstract:
Observed biological activities of substituted phenyl urea/thiourea tetrapeptides as agonists with the cholecystokinin-alimentary canal (CCK-A) receptor, and (R)-4-benzamido-5-oxopentanoic acid derivatives with both peripheral (CCK-A) and the central (CCK-B) (brain) receptors have been shown to be correlated with various physicochemical, e.g. pi, sigma, and structural, e.g. Vw and dummy, I, parameters. These results were, then interpreted to predict promising criteria for having ligands with better affinity with the CCK receptors.