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Evaluation of temperature sensitivity of human papillomavirus type 11 by using the human xenograft severe combined
W Bonnez1, R C Rose, C Borkhuis
1Department of Medicine, University of Rochester School of Medicine and Dentistry, New York 14642.
Journal of Clinical Microbiology
|June 1, 1994
Abstract:
The temperature sensitivity of human papillomavirus type 11 was evaluated by using a human xenograft severe combined immunodeficiency mouse model. Incubation of the virus for 1 h at a temperature higher than 56 degrees C but lower than 72 degrees C was sufficient to inhibit the virally induced growth of infected human tissue. However, 100 degrees C was necessary to completely inactivate HPV type 11 genome expression.