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Building-related illnesses

J M Seltzer1

  • 1University of California, San Diego.

The Journal of Allergy and Clinical Immunology
|August 1, 1994
PubMed
Summary
This summary is machine-generated.

Building-related illnesses stem from indoor environmental factors affecting health. This review details how agents cause these illnesses through immunologic, infectious, toxic, or irritant mechanisms, impacting skin and respiratory health.

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Area of Science:

  • Environmental Health
  • Occupational Medicine
  • Toxicology

Background:

  • Growing awareness of indoor environment's impact on human health.
  • Building-related illness (BRI) defined as adverse health effects with a clear link to specific indoor environmental agents.
  • Illnesses often affect skin and respiratory tracts due to direct contact with indoor contaminants.

Purpose of the Study:

  • To elucidate the pathophysiologic mechanisms underlying building-related illnesses.
  • To categorize the different types of illnesses caused by indoor environmental factors.
  • To review the evidence linking specific environmental agents to resultant health disorders.

Main Methods:

  • Review of scientific literature on building-related illnesses.

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  • Analysis of etiological mechanisms (immunologic, infectious, toxic, irritant).
  • Examination of evidence validating agent-disease connections.

    • Main Results:

    • Building-related illnesses are caused by environmental agents acting via distinct pathophysiologic pathways.
    • Four primary mechanisms identified: immunologic, infectious, toxic, and irritant.
    • Some agents may trigger illness through multiple mechanisms.

    Conclusions:

    • Understanding the mechanisms of BRI is crucial for defining and addressing adverse health effects from indoor environments.
    • Clear links between indoor environmental agents and specific health disorders are established.
    • Further research can refine our understanding of BRI pathogenesis and prevention.