Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nonhuman primate restraint device for ocular drug studies

W J Casey, B K Hart, W A Tarleton

    Laboratory Animal Science
    |August 1, 1975
    PubMed
    Summary

    A novel restraining device for nonhuman primates prevents eye-touching, enabling reliable drug testing by using one eye as a control. This method ensures accurate pharmacologic effect observation without causing animal distress.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Open-path FT-IR spectrometry: is completely unattended operation feasible?

    Talanta·2008
    Same author

    Phosphorus removal from municipal wastewater by hydrous ferric oxide reactive filtration and coupled chemically enhanced secondary treatment: part I--performance.

    Water environment research : a research publication of the Water Environment Federation·2008
    Same author

    Prophylactic inferior vena cava filters in trauma patients at high risk: follow-up examination and risk/benefit assessment.

    Journal of vascular surgery·1999
    Same author

    Is renal revascularization in diabetic patients worthwhile?

    Journal of vascular surgery·1996
    Same author

    Characterization of a dinucleotide repeat in the 92 kDa type IV collagenase gene (CLG4B), localization of CLG4B to chromosome 20 and the role of CLG4B in aortic aneurysmal disease.

    Annals of human genetics·1995
    Same author

    Dinucleotide repeat polymorphism at the HPR locus.

    Human molecular genetics·1994

    Area of Science:

    • Veterinary Ophthalmology
    • Pharmacology
    • Animal Behavior

    Background:

    • Topical drug administration in nonhuman primates often leads to inaccurate results due to eye-touching.
    • Lack of a reliable control method hinders accurate pharmacologic effect assessment.
    • Existing methods may cause animal distress or interfere with self-care.

    Purpose of the Study:

    • To design and evaluate a restraining device for nonhuman primates.
    • To prevent topical drug transfer between eyes.
    • To enable the use of a single animal as its own control for drug studies.

    Main Methods:

    • A custom restraining device was designed and implemented for nonhuman primates.
    • The device prevented animals from touching their eyes.
    • The device allowed for self-feeding and was monitored for adverse effects.

    Main Results:

    • The device effectively prevented eye-touching and drug transfer.
    • One eye could be reliably used as a control for pharmacologic observations.
    • No chafing, pressure sores, or psychologic depression were observed in the animals.
    • The device was successfully used for a 5-month period.

    Conclusions:

    • The developed restraining device is effective and humane for nonhuman primates.
    • It facilitates accurate topical drug testing by enabling within-subject controls.
    • This innovation improves the reliability and ethics of nonhuman primate drug studies.

    Related Experiment Videos