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The relation between ABO blood groups, HLA typing and giardiasis in children
G A el-Ganayni1, R A Attia, S M Motawea
1Department of Parasitology, Faculty of Medicine, Mansoura University, Egypt.
Journal of the Egyptian Society of Parasitology
|August 1, 1994
Summary
Children with blood group A showed increased susceptibility to giardiasis, particularly the asymptomatic form. Specific Human Leukocyte Antigen (HLA) types were associated with symptomatic and asymptomatic giardiasis.
Area of Science:
- Immunology
- Infectious Diseases
- Pediatrics
Background:
- Giardiasis is a common intestinal infection caused by Giardia lamblia.
- Host factors, including genetic predispositions, may influence susceptibility to giardiasis.
Purpose of the Study:
- To investigate the association between ABO blood groups, Human Leukocyte Antigen (HLA) phenotypes, and susceptibility to giardiasis in children.
- To differentiate associations for symptomatic versus asymptomatic giardiasis.
Main Methods:
- A case-control study involving 91 children with giardiasis and 101 giardiasis-free children.
- Stool examinations for giardiasis diagnosis.
- Analysis of ABO blood groups and HLA typing.
Main Results:
- Blood group A demonstrated higher susceptibility to giardiasis, especially the asymptomatic form.
- Blood group B showed decreased susceptibility.
- No significant association was found between blood groups AB or O and giardiasis.
- Strong associations were observed between specific HLA phenotypes (A10, A11, B5, B7, B17) and symptomatic giardiasis.
- Associations were also noted between HLA (B7, B17, Bw14, Bw40) and asymptomatic giardiasis.
Conclusions:
- ABO blood group A is a risk factor for giardiasis in children.
- Specific HLA alleles are significantly associated with symptomatic and asymptomatic giardiasis, suggesting a genetic component in disease presentation.