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Related Experiment Videos

Liver reactions from trimethoprim

A Lindgren1, R Olsson

  • 1Department of Medicine, Sahlgrenska University Hospital, Göteborg, Sweden.

Journal of Internal Medicine
|September 1, 1994
PubMed
Summary
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Trimethoprim rarely causes adverse liver reactions, with a probable causal link in only 10 cases over a decade. These reactions were similar to trimethoprim-sulfonamide combinations, but less severe than sulfonamide-only drugs.

Area of Science:

  • Pharmacovigilance
  • Hepatology
  • Drug Safety

Background:

  • Adverse drug reactions (ADRs) are a significant concern in clinical practice.
  • Trimethoprim is a widely used antibiotic, often prescribed alone or in combination.
  • Understanding the specific liver toxicity profile of trimethoprim is crucial for patient safety.

Purpose of the Study:

  • To investigate the occurrence of adverse liver reactions associated with trimethoprim use.
  • To characterize the biochemical patterns of trimethoprim-induced liver injury.

Main Methods:

  • A comprehensive survey of liver-related ADRs reported to the Swedish Adverse Drug Reactions Advisory Committee (SADRAC) between 1980 and 1989.
  • Analysis of trimethoprim sales data in defined daily doses (DDD) to calculate incidence rates.

Related Experiment Videos

  • Comparison of reaction patterns with trimethoprim-sulfonamide combinations and sulfonamide monotherapy.

    • Main Results:

    • Twenty-one suspected liver reactions to trimethoprim were reported during the study period.
    • A probable causal relationship was established in 10 cases, yielding an incidence of 1 per 1,360,000 DDD.
    • The liver reaction profile for trimethoprim closely resembled that of trimethoprim-sulfonamide combinations.
    • Sulfonamide monotherapy showed a higher proportion of severe hepatocellular reactions compared to trimethoprim.

    Conclusions:

    • Trimethoprim is associated with a low incidence of adverse liver reactions.
    • The hepatotoxicity profile of trimethoprim is relatively mild and distinct from that of sulfonamides alone.
    • Continued monitoring of trimethoprim for potential liver injury is warranted.