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Sucralfate suspension as a treatment of recurrent aphthous stomatitis
J Rattan1, M Schneider, N Arber
1Department of Gastroenterology, Tel Aviv Medical Centre, Sackler School of Medicine, Israel.
Design:
A prospective randomized, double-blind, placebo-controlled, cross-over clinical trial.
Setting:
A university hospital.
Subjects:
Twenty-one patients with symptomatic recurrent aphthous stomatitis (RAS), unresponsive to conventional treatment were enrolled. They were divided into three groups.
Intervention:
In a cross-over trial, the patients received an oral suspension of sucralfate, an antacid solution or a placebo for 2 years.
Results:
After 2 years of follow-up, sucralfate was found to be superior to both placebo and antacid (P < 0.001) with regard to duration of pain, reduction of the healing period, response time to first treatment and duration of remission.
Conclusion:
Sucralfate suspension should be added to the armament of treatment modalities of RAS.