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An interaction between Gemfibrozil and alpha 1-antitrypsin

S Janciauskiene1, S Eriksson

  • 1Lund University, Department of Medicine, Malmö General Hospital, Sweden.

Journal of Internal Medicine
|September 1, 1994
PubMed
Summary
This summary is machine-generated.

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Gemfibrozil, a lipid-lowering drug, interacts with alpha 1-antitrypsin (alpha 1-AT), altering its properties. This interaction reduces alpha 1-AT activity in both deficient and non-deficient patients, as observed in vitro.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Proteomics

Background:

  • Hydrophobic compounds like cholesterol and lithocholic acid are known to interact with alpha 1-antitrypsin (alpha 1-AT).
  • Alpha 1-antitrypsin is a crucial inhibitor protein protecting tissues from proteolytic damage.

Observation:

  • An interaction was observed between the anionic, hydrophobic drug Gemfibrozil and alpha 1-AT in a patient with alpha 1-AT deficiency (PiZZ).
  • This interaction was found to affect the physicochemical and antiproteinase properties of alpha 1-AT.

Findings:

  • Gemfibrozil treatment led to a reduction in alpha 1-AT activity in the PiZZ patient.
  • Similar reductions in alpha 1-AT activity were observed in non-PiZ patients and could be replicated in vitro, confirming Gemfibrozil's direct effect.

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Implications:

  • Gemfibrozil's interaction with alpha 1-AT may have clinical relevance, particularly in individuals with or without alpha 1-AT deficiency.
  • Understanding this interaction is important for evaluating the safety and efficacy of Gemfibrozil, especially concerning its impact on protease inhibition.