Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Nasal NK-cell lymphoma]

J Fukuda1, T Yoshihara, Y Arai

  • 1Department of Hematology, Tokyo Women's Medical College.

[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|June 1, 1994
PubMed
Summary

This study identifies a rare nasal lymphoma in a patient, revealing it originated from activated Natural Killer (NK) cells infected by the Epstein-Barr virus (EBV). This finding may explain chemotherapy resistance in nasal lymphomas.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A population-based assessment of the drug interaction between levothyroxine and warfarin.

Clinical pharmacology and therapeutics·2012
Same author

Nanostructured Si-nanowire microarrays for enhanced-performance bio-analytics.

Lab on a chip·2012
Same author

Upregulated ataxia-telangiectasia group D complementing gene correlates with poor prognosis in patients with esophageal squamous cell carcinoma.

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus·2012
Same author

Mitotoxicity and bortezomib-induced chronic painful peripheral neuropathy.

Experimental neurology·2012
Same author

Effects of temperature and trehalose on foam separation of nisin from the culture broth produced by Lactococcus lactis subspecies lactis W28.

Journal of dairy science·2012
Same author

Dynamics of wicking in silicon nanopillars fabricated with interference lithography and metal-assisted chemical etching.

Langmuir : the ACS journal of surfaces and colloids·2012

Area of Science:

  • Oncology
  • Immunology
  • Virology

Background:

  • Nasal lymphomas are rare and often present with non-specific symptoms.
  • Diagnosis typically involves biopsy and immunophenotyping.

Observation:

  • A 75-year-old male presented with nasal obstruction, epistaxis, fever, night sweats, and weight loss.
  • A nasal biopsy revealed a diffuse, mixed-type non-Hodgkin's lymphoma with cytoplasmic azurophilic granules.
  • Tumor cells exhibited specific CD markers (CD2+, CD7+, CD16+, CD56+) and lacked T cell receptor gene rearrangement.

Findings:

  • The tumor cells demonstrated strong Natural Killer (NK) cell activity.
  • Immunophenotypic and cytotoxic analyses suggested derivation from activated NK cells.
  • Epstein-Barr virus (EBV) positivity and CD21 antigen expression indicated EBV-infected NK cell transformation.

Related Experiment Videos

  • Multidrug resistance P-glycoprotein was also detected in tumor cells.

    • Implications:

    • This case suggests a potential origin of nasal lymphoma from EBV-infected, activated NK cells.
    • The presence of MDR P-glycoprotein may contribute to the observed chemotherapy resistance and poor prognosis in nasal lymphomas.
    • Understanding the cellular origin and molecular mechanisms is crucial for developing targeted therapies.