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[Regional immunocorrective therapy using laferon in patients with suppurative cholangitis]
Klinicheskaia Khirurgiia
|January 1, 1994
Summary
Intracholedochal laferon administration improved immune function and reduced inflammation in patients with purulent cholangitis. This novel approach led to the normalization of abnormal blood test results, aiding recovery.
Area of Science:
- Immunology
- Gastroenterology
- Pharmacology
Background:
- Purulent cholangitis is a severe biliary tract infection requiring prompt management.
- Current treatments often involve antibiotics and drainage, but immune modulation can be beneficial.
Purpose of the Study:
- To evaluate the efficacy of intracholedochal laferon in patients with purulent cholangitis.
- To assess the impact of laferon on immune response and inflammatory markers.
Main Methods:
- Patients with purulent cholangitis received intracholedochal laferon alongside standard antibacterial and supportive therapy.
- Immune function, autoimmune response, and general inflammatory markers were monitored.
Main Results:
- Laferon administration enhanced cellular immunity function.
- A decrease in the intensity of autoimmune responses mediated by lymphocytes was observed.
- Stabilization of the systemic inflammatory response occurred.
- Pathologically elevated laboratory and biochemical indices normalized.
Conclusions:
- Intracholedochal laferon is a potentially effective adjunctive therapy for purulent cholangitis.
- Laferon modulates the immune system and reduces inflammation, improving clinical outcomes.