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A Reverse Genetic Approach to Test Functional Redundancy During Embryogenesis
Published on: August 11, 2010
An early haematopoietic defect in mice lacking the transcription factor GATA-2
1Division of Hematology-Oncology, Children's Hospital, Boston, Massachusetts.
Nature
|September 15, 1994
Abstract:
Blood cell development relies on the expansion and maintenance of haematopoietic stem and progenitor cells in the embryo. By gene targeting in mouse embryonic stem cells, we demonstrate that the transcription factor GATA-2 plays a critical role in haematopoiesis, particularly of an adult type. We propose that GATA-2 regulates genes controlling growth factor responsiveness or the proliferative capacity of early haematopoietic cells.
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