[Development of immune response to the combined action of hepatotropic poisons and high ambient temperature]

The experiments on Wistar rats have shown that administration of the hepatotropic poisons tetrachloromethane and polychlorpinene increased an immune response to T-dependent antigens. The combined exposure of the body to the hepatotropic poisons and high ambient temperatures leads to a drastically marked inhibition of immune responses to T-dependent and T-independent antigens. High ambient temperatures enhance a release of a comparatively high-molecular weight immuno-suppressor factor in tetrachloromethane-intoxicated rats, as well as induce production of a comparatively low-molecular weight immunosuppressor factor in the intoxicated rats who retain their splenocytic capacity of generating a low-molecular weight immunostimulating factor. The higher sensitivity retain their splenocytic capacity of generating a low-molecular weight immunostimulating factor. The higher sensitivity of splenocytes from rats with toxic hepatic lesion to elevated ambient temperatures is accounted for by their influence on humoral factors of intoxicated animals' sera.