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Related Experiment Videos

Nucleic acid sequences coding for internal antisense peptides: are there implications for protein folding and

J E Zull1, R C Taylor, G S Michaels

  • 1Department of Biology, Case Western Reserve University, Cleveland, OH 44106.

Nucleic Acids Research
|August 25, 1994
PubMed
Summary

Coding segments of nucleic acids do not appear to generate internal antisense amino acid sequences related to protein structure. Analysis suggests evolutionary selection may actively reduce internal antisense in the primary reading frame.

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Area of Science:

  • Molecular Biology
  • Bioinformatics
  • Genomics

Background:

  • The study investigates 'Internal Antisense' in amino acid sequences derived from nucleic acid coding segments.
  • It explores a potential link between internal antisense content and the three-dimensional structure of encoded proteins.

Purpose of the Study:

  • To determine if nucleic acid coding sequences generate internal antisense amino acid sequences.
  • To assess if internal antisense content correlates with protein structure.

Main Methods:

  • Computer searches of coding sequences from 132 proteins were performed.
  • Results were compared against 1000 random nucleic acid chains of identical length and base composition.
  • Analysis was conducted across all three reading frames.

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Main Results:

  • The primary reading frame (frame one) showed lower internal antisense than random sequences.
  • Frames two and three exhibited significantly higher internal antisense.
  • Internal antisense in frames two and three correlated with GC content, but not chain length; frame one did not show this correlation.

Conclusions:

  • Internal antisense in the primary reading frame (frame one) may be under evolutionary selection against it.
  • High internal antisense in frames two and three appears to be an artifact of codon GC content asymmetry.
  • The study does not support a relationship between internal antisense and protein structure.