[Acute inflammatory polyradiculoneuritis during bone marrow transplantation. A report of 2 cases]

Acute polyradiculoneuritis (AP) is a self-immunity based disease of the peripheral nerve caused by macrophages, usually activated by T-lymphocytes. Recent clinical and experimental evidence show that early high dose treatment with Ig slows disease progression. In this study, two cases of AP with different onset in two patients showing definitely compromised cellular and/or humoral immunity, are reported. The hypothesis that the different temporal profiles may be related to a distinct involvement of the immunity system and the effectiveness of high dose Ig treatment in blocking the disease's evolution are discussed.