[Severe acute asthma in adults]

Despite a better understanding of the physiopathology of asthma and the availability of potent drugs, severe acute asthma is still a frequent cause of death (1500 to 2000 patients die each year of asthma in France). Among the different clinical presentations, hyperacute attack with an attack duration (period from onset of attack to mechanical ventilation or to fatality) of less than 3 hours has to be individualized. The agents of choice in the treatment of acute life-threatening asthma are oxygen, beta-adrenergic sympathomimetic amines given intravenously or by nebulization, and corticosteroids. Theophylline is not any more the first choice of treatment but should not be rejected. Anticholinergics given by nebulization in combination with sympathomimetic agents are effective. Beside these treatment, hydratation and antibiotics are important adjunctive treatment. Mechanical ventilation is rarely necessary but has to be instituted either in emergency in case of near fatal asthma or electively because of deterioration of clinical status and blood gases, despite full medical treatment.