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Lymphocytopenia and occupational exposures among pattern and model makers
P A Demers1, W J Schade, R Y Demers
1Occupational Hygiene Program, University of British Columbia, Vancouver, Canada.
Scandinavian Journal of Work, Environment & Health
|April 1, 1994
Summary
Occupational exposure to epoxy resins and plastic dusts may increase the risk of lymphocytopenia, a condition characterized by low lymphocyte counts. Further research is needed to confirm these findings in pattern and model makers.
Area of Science:
- Occupational health
- Immunotoxicology
- Industrial hygiene
Background:
- Lymphocytopenia, a decrease in lymphocyte count, was observed in a cancer screening program for pattern and model makers.
- This study investigated potential links between lymphocytopenia and occupational exposures in this industry.
Purpose of the Study:
- To examine the relationship between lymphocytopenia and 15 specific occupational exposures in pattern and model makers.
- To identify workplace factors contributing to reduced lymphocyte counts.
Main Methods:
- Case-control study comparing workers with low lymphocyte counts (cases, N=83) to those with normal counts (referents, N=529).
- Occupational exposures were assessed via questionnaire, covering current and previous workplaces.
- Statistical analysis, including odds ratios (OR) and 95% confidence intervals (95% CI), adjusted for age and smoking.
Main Results:
- Elevated risks of lymphocytopenia were associated with exposure to epoxy resins (OR 1.94) and plastic dusts (OR 2.60).
- No significant associations were found with exposure duration or percentage of time exposed.
- Epoxy resins and wood dust showed consistent relationships with lymphocyte count changes over time, despite small sample sizes.
Conclusions:
- The study suggests a potential association between epoxy resin exposure and lymphocytopenia.
- While not definitive, epoxy resin exposure presents the strongest observed link to reduced lymphocyte counts in this cohort.