[Changes in the mechanical integration of transitional epithelial cells and in the immune status of patients with...

Mutual adhesiveness of urothelial tissue cells have been studied in healthy donors and patients with benign and malignant bladder tumors. The decreased mutual adhesiveness has been shown not only for tumors, but for surrounding urothelial tissue as well. Urothelial tissue integration, T-cell immunity and parameters of leukocyte integrins were affected most of all in bladder tumor stage T2 and T3. Basing on these findings, the authors recommend conservative therapy only in superficial bladder cancer.