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Defibrination in obstetrics. Modern concepts

G J Kleiner, W M Greston

    South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
    |March 19, 1975
    PubMed
    Summary
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    This study examines coagulation factors during normal pregnancy and delivery, as well as in complicated pregnancies. Findings provide a basis for managing obstetric defibrination effectively.

    Area of Science:

    • Obstetrics and Gynecology
    • Hematology
    • Reproductive Medicine

    Background:

    • Coagulation profiles are crucial during pregnancy and childbirth.
    • Understanding hemostasis in obstetric complications is vital for patient management.
    • Defibrination is a serious complication in obstetrics.

    Purpose of the Study:

    • To present coagulation profiles (fibrinogen, factors V and VIII, hemoglobin) in normal pregnancies during labor, delivery, and the puerperium.
    • To investigate these coagulation factors in pregnancies complicated by abruptio placentae, intrauterine death, and termination via intra-amniotic saline or prostaglandin F2alpha.
    • To assess fibrinolytic activity using both qualitative and quantitative methods in these patient groups.

    Main Methods:

    • Analysis of serum fibrinogen, factors V and VIII, and hemoglobin levels.

    Related Experiment Videos

  • Evaluation of euglobulin lysis time (qualitative) and FR-antigen (quantitative) for fibrinolytic activity.
  • Comparative study across normal pregnancy, abruptio placentae, intrauterine death, and pregnancy termination groups.

    • Main Results:

    • Detailed coagulation profiles were established for normal pregnancies throughout the peripartum period.
    • Significant alterations in coagulation factors and fibrinolytic activity were observed in complicated pregnancies.
    • Specific patterns of coagulation changes were identified in abruptio placentae, intrauterine death, and medically terminated pregnancies.

    Conclusions:

    • The presented coagulation findings offer a foundation for the rational management of defibrination syndrome in obstetric patients.
    • Understanding these hemostatic changes is essential for timely and appropriate clinical intervention.
    • This research contributes to improved diagnostic and therapeutic strategies for obstetric hemorrhage and coagulation disorders.