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Ion trap mass spectrometry. Using high-pressure ionization

S A McLuckey, G J Van Berkel, D E Goeringer

    Analytical Chemistry
    |July 15, 1994
    PubMed
    Summary
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    The quadrupole ion trap, using a bath gas, offers efficient ion capture and analysis for mass spectrometry. This technique enhances detection limits, making it ideal for techniques like electrospray ionization.

    Area of Science:

    • Analytical Chemistry
    • Mass Spectrometry Instrumentation

    Background:

    • Quadrupole ion traps function as mass analyzers with unique characteristics.
    • They share similarities with Ion Cyclotron Resonance (ICR) instruments but differ in bath gas use and mass analysis principles.

    Purpose of the Study:

    • To explore the capabilities of quadrupole ion traps as mass analyzers.
    • To highlight their advantages in ion capture, cooling, and mass analysis.

    Main Methods:

    • Operation of a quadrupole ion trap with a high-pressure bath gas.
    • Utilizing mass-selective instability for ion analysis.
    • Employing collisional activation for ion dissociation.

    Main Results:

    • Bath gas aids ion capture, cooling, and heating within the trap.

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  • Collisional activation can dissociate ion clusters and covalently bound ions.
  • Ion traps offer higher efficiency and lower detection limits compared to beam-type mass spectrometers.

    • Conclusions:

    • Quadrupole ion traps are effective for high-pressure ionization methods due to moderate pressure requirements.
    • Their efficiency advantages are significant for weak ion beams and electrospray ionization (ESI).
    • Ion traps enable structural information acquisition and destruction of polyatomic species in elemental analysis.