Related Experiment Videos
[Blood ethanol levels and the CTP2E1 C2 allele]
K Iwahashi1, R Miyatake, H Suwaki
1Department of Neuropsychiatry, Kagawa Medical School, Japan.
Arukoru Kenkyu to Yakubutsu Izon = Japanese Journal of Alcohol Studies & Drug Dependence
|June 1, 1994
Abstract:
The effect of CYP2E1 upon the blood ethanol level was investigated. Blood ethanol concentrations in 2 volunteers whose ADH2, ADH3 and ALDH2 genotypes were identical, were determined after intravenous administrations of 0.15 g/kg of ethanol by gas chromatography. beta 60 (0.28 mg/ml/hr) of the blood ethanol concentration-time curve in one with the CYP2E1 C2 allele was higher than that (0.25 mg/ml/hr) in the other with no C2 allele. It is possible that the C2 allele may correspond to the higher CYP2E1 activity of ethanol metabolism.