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Culturing and Maintaining Clostridium difficile in an Anaerobic Environment
11:13

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Published on: September 15, 2013

Decrease in nosocomial Clostridium difficile-associated diarrhea by restricting clindamycin use

S M Pear1, T H Williamson, K M Bettin

  • 1Veterans Affairs Medical Center, Tucson, AZ.

Annals of Internal Medicine
|February 15, 1994
PubMed
Summary
This summary is machine-generated.

A hospital outbreak of Clostridium difficile-associated diarrhea was investigated and controlled. Restricting the use of clindamycin, an antibiotic linked to the epidemic, effectively reduced infection rates.

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Area of Science:

  • Infectious Diseases
  • Hospital Epidemiology
  • Antimicrobial Stewardship

Background:

  • Nosocomial infections pose a significant threat to patient safety.
  • Clostridium difficile-associated diarrhea (CDAD) is a common healthcare-associated infection.
  • Identifying and controlling outbreaks is crucial for patient care.

Purpose of the Study:

  • To investigate the cause of a nosocomial epidemic of Clostridium difficile-associated diarrhea.
  • To implement and evaluate control measures for the epidemic.
  • To analyze the role of antibiotic use in the outbreak.

Main Methods:

  • Concurrent surveillance for new nosocomial cases.
  • Retrospective case-control analysis.
  • Hospital formulary control of antibiotic use, specifically clindamycin.

Main Results:

  • A significant increase in CDAD incidence was observed over 13 months.
  • Clindamycin use was statistically associated with the epidemic.
  • Restriction of clindamycin use led to a prompt decrease in infection rates.

Conclusions:

  • Analysis of antibiotic use patterns identified clindamycin as a key factor in the CDAD epidemic.
  • Restriction of clindamycin use was an effective control strategy.
  • This study highlights the importance of antimicrobial stewardship in preventing and managing nosocomial infections.