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Structure-activity relationships of antitumor thiazolo[3,4-a]benzimidazole derivatives
A Chimirri1, S Grasso, A M Montforte
1Dipartimento Farmaco-Chimico, Università di Messina.
Farmaco (Societa Chimica Italiana : 1989)
|May 1, 1994
Abstract:
A series of thiazolo[3,4-a]benzimidazole derivatives were evaluated in vitro as antitumor agents against 60 human tumor cell-lines. The influence on the antitumor activity of the nature and type of substitution on the phenyl ring at C-1 is examined and a preliminary quantitative structure-activity relationships is presented.