Differential pulse polarographic determination of nizatidine in pharmaceutical formulations

A sensitive dp polarographic method was applied to the analytical determination of nizatidine, a new histamine H2-receptor antagonist. Determination was performed in Britton-Robinson buffer, at pH approximately equal to 3, ionic strength mu = 0.2. Linear dependence was achieved in a concentration range of 1.33 to 165.72 micrograms/ml for different sensitivities. The method proposed was applied to the determination of nizatidine in capsules and injections.