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Evaluation of a morpholinothiolporphyrin for use in photodynamic therapy
K W Woodburn1, J S Hill, S Stylli
1Department of Biochemistry, La Trobe University, Bundoora, Australia.
British Journal of Cancer
|September 1, 1994
Abstract:
The photonecrotic effectiveness of a morpholinothiolporphyrin derived from haematoporphyrin was measured in an animal model of cerebral glioma. The dose administered was 20 mg kg-1 and the laser dose varied from 0 to 200 J cm-2. The tumour necrosis was at least as good as that of HpD, and this therapeutic response may be attributed to the targeting of specific 'photopotent' subcellular sites.