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Clozapine treatment and its effect on neuroendocrine responses induced by the serotonin agonist,
R S Kahn1, M Davidson, L J Siever
1Department of Psychiatry, Mount Sinai School of Medicine/Bronx Veterans Administration Hospital, New York, NY.
Biological Psychiatry
|June 15, 1994
Abstract:
The effects of clozapine treatment on neuroendocrine responses induced by the serotonin agonist, m-chlorophenylpiperazine (mCPP) were examined. mCPP and placebo were administered after a 2-week drug-free period and again after 5 weeks of clozapine treatment in nine schizophrenic inpatients. Adrenocorticotropic hormone (ACTH), prolactin, and mCPP levels were measured. Clozapine treatment completely blocked mCPP-induced ACTH and prolactin release suggesting that clozapine blocks serotonin receptors that mediate these hormone responses.