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Related Experiment Videos

Antithrombin in infancy and childhood

A Catrine, T Nilsson

    Acta Paediatrica Scandinavica
    |July 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Antithrombin III levels and activity in infants are lower than in adults, increasing with age. Immunological measurement was lower than activity in infants under one month.

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    Area of Science:

    • Biochemistry
    • Pediatric Medicine
    • Hematology

    Background:

    • Antithrombin III is a crucial anticoagulant protein.
    • Understanding its development in infants is important for clinical practice.

    Purpose of the Study:

    • To compare immunological antithrombin III concentration with its activity in healthy children.
    • To assess the age-related changes in antithrombin levels and activity.

    Main Methods:

    • Plasma samples from healthy infants and children (0-14 years) were analyzed.
    • Antithrombin III concentration was measured using an immunological assay.
    • Antithrombin activity was determined using a novel synthetic tripeptide substrate for serine proteases.

    Main Results:

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    • Both methods showed lower values in young infants compared to adults.
    • Antithrombin levels and activity increased with age, reaching adult levels around 6 months.
    • In infants <1 month, immunological antithrombin III was significantly lower than its activity.
    • A poor correlation was observed between antithrombin III concentration and activity.

    Conclusions:

    • Antithrombin III levels and activity mature significantly during early infancy.
    • Discrepancies between immunological and functional assays exist in neonates.
    • Age-specific reference ranges for antithrombin are necessary for pediatric populations.