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Related Experiment Videos

Systemic absorption and abuse liability of snorted flunitrazepam

A Bond1, D Seijas, S Dawling

  • 1Department of Psychiatry, Institute of Psychiatry, University of London, UK.

Addiction (Abingdon, England)
|July 1, 1994
PubMed
Summary

Snorting flunitrazepam, a benzodiazepine hypnotic, leads to rapid detection in blood. Higher doses increase peak plasma concentrations, correlating with user-reported drug liking and strength.

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Area of Science:

  • Pharmacology
  • Forensic Toxicology
  • Clinical Pharmacology

Background:

  • Benzodiazepine hypnotics are frequently misused within polydrug abuse patterns.
  • Understanding novel routes of administration, such as snorting, is crucial for addressing drug abuse.

Purpose of the Study:

  • To investigate the pharmacokinetic and pharmacodynamic properties of snorted flunitrazepam.
  • To assess the safety and subjective effects of snorting flunitrazepam.

Main Methods:

  • A pharmacokinetic study involving 20 healthy volunteers who received varying doses of flunitrazepam via snorting or placebo.
  • Blood sampling at multiple time points post-administration to measure flunitrazepam levels.
  • Subjective ratings of mood, drug strength, and liking were collected.

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Main Results:

  • Flunitrazepam was detectable in blood within 5 minutes of snorting.
  • Increasing doses led to higher peak plasma concentrations, occurring later.
  • Subjective reports indicated sedation, drug liking, and correlated strength ratings with plasma levels.

Conclusions:

  • Snorting flunitrazepam results in rapid absorption and detectable blood levels.
  • The subjective effects, including liking and perceived strength, are dose-dependent and linked to plasma concentrations.