Related Experiment Video
Updated: Aug 8, 2026

Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis
Published on: August 7, 2018
Toxic epidermal necrolysis
1Gundersen Clinic, Ltd., LaCrosse, Wisconsin 54601.
Abstract:
Toxic epidermal necrolysis (TEN) is a potentially severe mucocutaneous affliction whose cause is usually drug related. TEN results in skin sloughing that resembles a partial thickness thermal injury. If the exposed dermis can be protected from infection, regeneration can occur. Podiatric surgeons are commonly involved in the management of lower extremity infections and utilize antibiotics, both orally and parenterally. This case study and review will familiarize the podiatric surgeon with the potential complications associated with drug-related interventions.
Related Concept Videos
Overview of Cell Death
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the 20th century...
Necrosis
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become anucleated and die, but their...
Clinical Applications of Epidermal Stem Cells
Bioactivation and Tissue Toxicity
Diphtheria
Cellular Injury IV: Necrosis

