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Infection and multiple sclerosis: a possible role for superantigens?
S Brocke1, T Veromaa, I L Weissman
1Dept of Neurology and Neurological Sciences, Stanford University Medical Center, CA 94305.
Trends in Microbiology
|July 1, 1994
Abstract:
The association of infection with autoimmune diseases is enigmatic, partly because cause and effect are difficult to establish in chronic diseases. Microorganisms might initiate multiple sclerosis and trigger relapses of disease. Superantigens might be involved in autoimmunity through the (re)activation of T cells, including autoreactive cells, expressing certain T cell receptor beta chain variable regions.