[The immunohistochemical study of p53 protein in primary lung cancer]

The expression of tumour suppressor gene P53 products-P53 protein in patients with primary lung cancer has been studied by ABC immunohistochemical method using McAb 1801 as probe. Abnormalities in P53 expression were found in 63 of 78 carcinomas, 23 of 26 squamous cell carcinomas, 23 of 29 adenocarcinomas, 7 of 11 large cell carcinomas, 7 of 9 small cell carcinomas and all 3 cases of adenoid cystic carcinomas showing abnormal P53 expression, whereas no expression of P53 was detectable in 11 normal lung samples. These findings suggest that the pathogenesis of lung cancer may also be related with abnormalities of P53 gene.