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Insulin sensitivity test using a somatostatin analogue, octreotide (Sandostatin)
A Mimura1, S Kageyama, M Maruyama
1Department of Internal Medicine (III), Jikei University School of Medicine, Tokyo, Japan.
Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|April 1, 1994
Summary
The steady-state plasma glucose (SSPG) method, using octreotide to suppress natural hormone release, reliably measures insulin sensitivity. This technique shows strong correlation with the established euglycemic hyperinsulinemic clamp method.
Area of Science:
- Endocrinology
- Metabolic Research
- Clinical Diagnostics
Background:
- Insulin resistance is a key factor in type 2 diabetes.
- Accurate assessment of insulin sensitivity is crucial for patient management.
- Existing methods like the hyperinsulinemic clamp can be complex and time-consuming.
Purpose of the Study:
- To validate the steady-state plasma glucose (SSPG) method for assessing insulin sensitivity.
- To compare the SSPG method with the gold-standard euglycemic hyperinsulinemic clamp technique.
- To evaluate the efficacy of octreotide in suppressing endogenous hormone secretion during the SSPG test.
Main Methods:
- Ten non-obese, insulin-dependent diabetic patients participated.
- The SSPG method involved intravenous infusion of octreotide, insulin, and glucose.
- Octreotide was used to suppress endogenous growth hormone, glucagon, and insulin secretion.
- The euglycemic hyperinsulinemic clamp technique was performed using an artificial endocrine pancreas (Biostator).
Main Results:
- A steady state was achieved by 90 minutes in the SSPG method.
- The SSPG method showed a significant correlation (r = 0.91, p < 0.001) with the glucose disposal rate (GDR) from the clamp technique.
- Octreotide effectively suppressed endogenous insulin, growth hormone, and glucagon secretion.
Conclusions:
- The SSPG method, utilizing octreotide, is a valid and reliable tool for measuring insulin sensitivity in humans.
- This method offers a practical alternative for assessing insulin sensitivity compared to the clamp technique.
- The findings support the use of SSPG with octreotide in clinical and research settings for evaluating insulin action.