Immune response profiles in responsive and non-responsive mouse strains infected with Heligmosomoides polygyrus

The immune response to a primary infection with Heligmosomoides polygyrus was monitored in three strains of mice (SJL, BALB/c, CBA) with different degrees of susceptibility to the infection. Parameters measured included circulating leucocyte numbers, T and B cell numbers in the mesenteric lymph nodes, the mucosal mast cell response, and quantitative and qualitative antibody responses to parasite antigens. From these data it would appear that resistance was governed by the relative speed and magnitude of the immune response mounted by the host. The possible immunological mechanisms governing this process are discussed.