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Related Experiment Videos

Brain hyperthermia: I. Interstitial microwave antenna array techniques--the Dartmouth experience

T P Ryan1, B S Trembly, D W Roberts

  • 1Radiation Oncology Section, Dartmouth Medical School, Hanover, NH.

International Journal of Radiation Oncology, Biology, Physics
|July 30, 1994
PubMed
Summary

Microwave antennas effectively heated brain tumors to therapeutic temperatures in patients. Four dipole antennas achieved significant heating volumes, demonstrating potential for advanced cancer treatment.

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Area of Science:

  • Biomedical Engineering
  • Oncology
  • Medical Physics

Background:

  • Hyperthermia therapy, using heat to treat cancer, is an established modality.
  • Microwave heating offers precise temperature control for targeted tumor treatment.
  • Developing effective microwave antenna arrays is crucial for uniform tumor heating.

Purpose of the Study:

  • To evaluate the efficacy of various microwave antenna designs for hyperthermia treatment of brain tumors.
  • To achieve target temperatures of 43.0 degrees C throughout the tumor volume.
  • To assess the heating capabilities and temperature distribution of different antenna configurations.

Main Methods:

  • Flexible microwave antennas (dipole, choke dipole, modified dipole, helical) were tested at 915 or 2450 MHz in brain-equivalent phantoms and patient arrays.

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  • Phase shifting and rotation techniques, guided by a treatment planning computer, were used to direct power within the tumor.
  • Choke antennas were specifically designed to minimize insertion depth dependency for consistent power delivery.

    • Main Results:

    • Twenty-three patients received treatment with one to six microwave antennas.
    • Average tumor temperatures ranged from 37.2-44.3°C (mean 40.0°C) minimum and 46.5-60.1°C (mean 49.1°C) maximum.
    • 70.9% of all measured temperatures reached the therapeutic threshold of ≥43.0°C, with T50 at 44.2°C.

    Conclusions:

    • An array of four dipole antennas spaced 2.0 cm apart demonstrated the ability to heat a significant volume.
    • This configuration could heat a volume of 5.9 cm x 2.8 cm x 2.8 cm, indicating effective tumor coverage.
    • The study validates the use of microwave antenna arrays for targeted hyperthermia in brain tumor treatment.