Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cytogenetic studies on commercial hexane solvent

W C Daughtrey1, D L Putman, J Duffy

  • 1Exxon Biomedical Sciences, Inc., E. Millstone, NJ 08875-2350.

Journal of Applied Toxicology : JAT
|May 1, 1994
PubMed
Summary

Commercial hexane, a solvent mixture, was tested for its ability to cause chromosome damage. Studies in both cell cultures and live rats found no evidence of hexane-induced chromosomal aberrations, indicating it is not mutagenic under tested conditions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

What are 'dark kitchens'? A consensus definition from public, local authority, business and academic stakeholders in the United Kingdom.

Perspectives in public health·2025
Same author

Metal mixtures and oral health among children and adolescents in the National Health and Nutrition Examination Survey (NHANES), 2017-2020.

International journal of hygiene and environmental health·2024
Same author

Peri-operative care of elective adult surgical patients with a learning disability.

Anaesthesia·2022
Same author

Functions of spontaneous and voluntary future thinking: evidence from subjective ratings.

Psychological research·2020
Same author

Use of progression criteria to support monitoring and commissioning decision making of public health services: lessons from Better Start Bradford.

BMC public health·2019
Same author

Collagen fibre orientation and dispersion govern ultimate tensile strength, stiffness and the fatigue performance of bovine pericardium.

Journal of the mechanical behavior of biomedical materials·2018

Area of Science:

  • Toxicology
  • Genetics
  • Occupational Health

Background:

  • Commercial hexane is a mixture of six-carbon isomers used as a solvent.
  • Understanding the genotoxic potential of industrial chemicals like hexane is crucial for occupational safety.

Purpose of the Study:

  • To evaluate the potential of commercial hexane to induce chromosome aberrations.
  • To assess the genotoxicity of commercial hexane in both in vitro and in vivo models.

Main Methods:

  • In vitro assay: Chinese hamster ovary (CHO) cells exposed to hexane with and without S-9 activation.
  • In vivo assay: Sprague-Dawley rats exposed to hexane vapor, followed by bone marrow cell analysis for chromosome aberrations.
  • Dose levels and exposure durations were systematically varied.

Related Experiment Videos

Main Results:

  • No statistically significant increase in chromosome aberrations was observed in CHO cells, even with metabolic activation.
  • In vivo studies showed no genotoxic effects in rat bone marrow cells across tested concentrations and time points.
  • Cellular toxicity was noted at high concentrations in vitro, but this did not correlate with mutagenicity.

Conclusions:

  • Commercial hexane did not demonstrate mutagenic potential by inducing chromosome aberrations in the conducted studies.
  • These findings suggest that commercial hexane is not a genotoxic agent under the evaluated experimental conditions.