Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Kainate receptor gene expression in the developing rat brain

S Bahn1, B Volk, W Wisden

  • 1MRC Laboratory of Molecular Biology, Neurobiology Division, Cambridge, United Kingdom.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|September 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identification and evaluation of barriers and facilitators to formal help-seeking for premenstrual symptoms in the UK: a mixed methods approach.

Frontiers in global women's health·2026
Same author

Improving care experiences for premenstrual symptoms and disorders in the United Kingdom (UK): a mixed-methods approach.

BMC health services research·2025
Same author

Fluoxetine, not donepezil, reverses anhedonia, cognitive dysfunctions and hippocampal proteome changes during repeated social defeat exposure.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology·2017
Same author

GABA Receptors and the Pharmacology of Sleep.

Handbook of experimental pharmacology·2017
Same author

Pathogen-mediated NMDA receptor autoimmunity and cellular barrier dysfunction in schizophrenia.

Translational psychiatry·2017
Same author

Serum proteomic profiles of depressive subtypes.

Translational psychiatry·2016
Same journal

A Matter of Parameters: Tailored Transcranial Focused Ultrasound Enhances Cortico-Thalamo-Cortical Circuit Resonance.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

Proactive visual and motor prioritization differentially scale with cue reliability.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

Erratum: Yao et al., "Estrogen Regulates Bcl-w and Bim Expression: Role in Protection against β-Amyloid Peptide-Induced Neuronal Death".

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

Erratum: L'Episcopo et al., "Plasticity of Subventricular Zone Neuroprogenitors in MPTP (1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine) Mouse Model of Parkinson's Disease Involves Cross Talk between Inflammatory and Wnt/β-Catenin Signaling Pathways: Functional Consequences for Neuroprotection and Repair".

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

Representations of subsecond duration-based timing by complex spike synchrony in cerebellar Purkinje neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

The extended language network: Language-responsive brain areas whose contributions to language remain to be discovered.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
See all related articles

Kainate receptor subunit gene expression in the developing rat brain reveals distinct patterns. These findings highlight the roles of specific kainate receptor subunits in neural development and function.

Area of Science:

  • Neuroscience
  • Developmental Biology

Background:

  • Kainate-preferring receptors, a subtype of ionotropic glutamate receptors, are implicated in brain development.
  • Understanding the spatiotemporal expression of kainate receptor subunits is crucial for deciphering their developmental roles.

Purpose of the Study:

  • To investigate the expression patterns of five kainate receptor subunit genes (GluR-5, -6, -7, KA-1, KA-2) during rat brain development.
  • To correlate gene expression with kainate binding sites using autoradiography.

Main Methods:

  • In situ hybridization was employed to study the expression of kainate receptor subunit genes (GluR-5, -6, -7, KA-1, KA-2) in the developing rat brain.
  • Autoradiography using 3H-kainate was used to map kainate binding sites.

Main Results:

Related Experiment Videos

  • Kainate receptor subunit mRNAs were detected early (E12), but protein binding emerged later (E14).
  • Distinct expression patterns were observed for each subunit, with peaks during the late embryonic/early postnatal period.
  • GluR-5 exhibited dynamic expression in sensory cortex, hippocampus, septum, and thalamus; GluR-6 in the neocortex; KA-1 in the hippocampus; and KA-2 throughout the CNS.
  • GluR-5 and GluR-6 were coexpressed in peripheral ganglia.

Conclusions:

  • The differential expression of kainate receptor subunits suggests specific roles in the development of distinct brain regions and peripheral nervous system structures.
  • These findings provide a detailed map of kainate receptor development, essential for understanding their contribution to neural circuitry formation and function.