Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Monocyte/macrophage system and malignancies

D Schmidt1

  • 1Institut für Pathologie, Mannheim, Germany.

Medical and Pediatric Oncology
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diagnostic assessment of two novel proliferation-specific antigens in benign and malignant melanocytic lesions.

The American journal of pathology·1995
Same author

[Placental site trophoblastic tumor. Morphology, differential diagnosis and prognosis].

Der Pathologe·1995
Same author

Retinal vascular hamartoma in von Hippel-Lindau disease.

Archives of ophthalmology (Chicago, Ill. : 1960)·1995
Same author

Dosimetry of iodine-123-epidepride: a dopamine D2 receptor ligand.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·1995
Same author

The use of CD31 and collagen IV as vascular markers. A study of 56 vascular lesions.

Pathology, research and practice·1995
Same author

[Fatigue fractures of the sacrum in primary biliary liver cirrhosis].

Aktuelle Radiologie·1995

Neoplasias of the monocyte/macrophage system, including malignant histiocytosis and dendritic cell sarcomas, are rare but characterizable. Most malignant histiocytosis cases are anaplastic large cell lymphoma (ALCL), while dendritic cell sarcomas have varied prognoses.

Area of Science:

  • Hematology
  • Oncology
  • Pathology

Background:

  • Neoplasias of the monocyte/macrophage system are uncommon hematologic malignancies.
  • These include malignant histiocytosis, dendritic cell sarcomas, and potentially malignant Langerhans cell histiocytosis.
  • Characterization relies on established methods for normal cellular counterparts.

Purpose of the Study:

  • To review and characterize rare neoplasms of the monocyte/macrophage system.
  • To discuss the diagnostic criteria and clinical behavior of these rare tumors.
  • To clarify controversies surrounding specific entities like malignant histiocytosis.

Main Methods:

  • Review of literature and case studies on monocyte/macrophage system neoplasms.
  • Immunohistochemical analysis for characterizing cellular origins and subtypes.

Related Experiment Videos

  • Clinical course and prognostic factor evaluation.

    • Main Results:

    • Malignant histiocytosis is often anaplastic large cell lymphoma (ALCL) with Ki1 expression, though true cases may lack Ki1.
    • Dendritic cell sarcomas include interdigitating and follicular types, with follicular dendritic cell sarcoma generally having a better prognosis.
    • Sarcomas of sinus lining cells are low-grade but recurrent, while malignant Langerhans cell histiocytosis exhibits aggressive behavior.

    Conclusions:

    • Neoplasms of the monocyte/macrophage system, though rare, can be characterized using established pathological lines.
    • Diagnostic clarification is needed for entities like malignant histiocytosis and malignant Langerhans cell histiocytosis.
    • Understanding the distinct behaviors and prognoses of these rare neoplasms is crucial for patient management.