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[Studies on hypophyseo-thyroid function in patients with chronic thyroiditis (author's transl)]

Nihon Naibunpi Gakkai Zasshi

|April 20, 1975

Summary

Elevated serum thyroid-stimulating hormone (TSH) levels are sensitive indicators of thyroid failure in chronic thyroiditis patients, even with normal thyroid function tests. The TRH-test detects minimal thyroid failure, especially in asymptomatic autoimmune thyroiditis.

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Area of Science:

Endocrinology
Immunology
Thyroidology

Context:

Chronic thyroiditis often presents with elevated serum TSH, a key indicator of subclinical hypothyroidism.
Thyroid function tests in these patients may appear normal despite underlying thyroid dysfunction.

Purpose:

To evaluate hypophyseo-thyroid functions in untreated euthyroid patients with chronic thyroiditis.
To assess the sensitivity of serum TSH levels and TRH-testing in detecting thyroid failure.

Summary:

Elevated basal TSH levels, with a mean of 12.9 muU/ml, were observed in euthyroid chronic thyroiditis patients, often with low-normal T4 and high-normal T3 levels.
TSH responses to TRH injection were exaggerated in most patients, correlating with basal TSH levels and indicating minimal thyroid failure.

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Asymptomatic autoimmune thyroiditis, suggested by positive antithyroglobulin antibodies and exaggerated TSH responses to TRH, was noted in patients with collagen diseases.

Impact:

Elevated basal TSH is a more sensitive marker of thyroid failure than routine tests in chronic thyroiditis.
The TRH-test is valuable for detecting minimal thyroid failure, particularly in cases of asymptomatic autoimmune thyroiditis.