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[Pulmonary involvement in sclerodermia]

G Paone1, L Di Michele, P Mattia

  • 1Dipartimento Scienze Cardiovascolari e Respiratorie, Università degli Studi di Roma La Sapienza.

Minerva Medica
|June 1, 1994
PubMed
Summary
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Progressive systemic sclerosis can cause lung inflammation (alveolitis) detectable by bronchoalveolar lavage and high-resolution computed tomography (HRCT). HRCT findings like ground glass appearance correlate with alveolitis, aiding diagnosis and monitoring of pulmonary involvement.

Area of Science:

  • Rheumatology and Pulmonology
  • Connective Tissue Diseases
  • Diagnostic Imaging

Context:

  • Progressive systemic sclerosis (PSS) is a fibrotic connective tissue disease with potential for significant pulmonary involvement.
  • Early PSS lung disease may not be apparent on standard chest radiography.
  • Traditional methods like pulmonary function tests and Gallium 67 scanning have limitations in predicting disease activity.

Purpose:

  • To evaluate the role of various diagnostic modalities in assessing pulmonary involvement in PSS.
  • To correlate findings from bronchoalveolar lavage (BAL) with imaging techniques, particularly high-resolution computed tomography (HRCT).
  • To determine the utility of HRCT in the diagnosis and follow-up of scleroderma-related lung disease.

Summary:

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  • Bronchoalveolar lavage (BAL) can identify alveolitis, characterized by increased neutrophils, in early PSS lung disease.
  • High-resolution computed tomography (HRCT) reveals ground glass appearance in early stages, correlating with BAL findings of alveolitis.
  • HRCT demonstrates progressive lung damage, including honeycomb changes, and is valuable for disease monitoring and activity assessment.

    • Impact:

    • Ground glass appearance on HRCT serves as a radiographic marker for alveolitis in PSS.
    • HRCT is a crucial tool for both diagnosing and tracking the progression and activity of pulmonary involvement in PSS.
    • This study enhances understanding of imaging in PSS, potentially improving patient management and outcomes.