Related Experiment Videos
Gangliosides modulate the development of ethyl-nitrosourea induced brain tumors in rats
J Vaquero1, C Morales, M Zurita
1Department of Neurosurgery, Puerta de Hierro Clinic, Autonomous University, Madrid, Spain.
Abstract:
The possible effect of gangliosides as biological modifiers of the ethyl-nitrosourea (ENU) model of neurocarcinogenesis in rats is studied. Wistar rats that were exposed to ENU during fetal life, were treated with gangliosides at a postnatal age corresponding to a stage of pretumor or microtumor development. The results obtained suggest that postnatal administration of gangliosides can influence the development of ENU-induced brain tumors, delaying the appearance of symptomatic neoplasms and improving survival with respect to controls. This finding suggests the potential usefulness of gangliosides in the control of neuroectodermal tumors.