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Related Experiment Videos

A 'pneumotaxic centre' in rats

J S Jodkowski1, S K Coles, T E Dick

  • 1Department of Medicine, Case Western Reserve University, Cleveland, OH 44106-5000.

Neuroscience Letters
|May 19, 1994
PubMed
Summary
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Pontine lesions caused apneustic breathing in rats, but intact vagi prevented this. Vagal stimulation partially reversed the breathing pattern, suggesting pontine neurons control respiration similarly across mammals.

Area of Science:

  • Neuroscience
  • Respiratory Physiology

Background:

  • The pons plays a critical role in respiratory control.
  • Previous studies suggest pontine structures influence breathing patterns.

Purpose of the Study:

  • To investigate the role of ventrolateral pons in respiratory control.
  • To determine if pontine neurons influence breathing similarly across mammalian species.

Main Methods:

  • Electrical and chemical lesions were induced in the ventrolateral pons of anesthetized, vagotomized, paralyzed, and ventilated adult rats.
  • Vagal stimulation was applied to assess its effect on breathing patterns.

Main Results:

  • Lesions in the ventrolateral pons resulted in apneustic breathing.
  • Apneustic breathing did not occur when vagi remained intact.

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  • Vagal stimulation partially reversed the apneustic breathing pattern.

    • Conclusions:

    • Ventrolateral pontine neurons are involved in regulating breathing patterns.
    • The findings support the hypothesis that pontine neurons influence breathing similarly across mammalian species.